10-HYDROXY-2-(E)-DECENOIC ACID
10-hydroxydec-2-enoic acid
CAS: 765-01-5;14113-05-4
Molecular Formula: C10H18O3
10-HYDROXY-2-(E)-DECENOIC ACID - Names and Identifiers
10-HYDROXY-2-(E)-DECENOIC ACID - Physico-chemical Properties
| Molecular Formula | C10H18O3 |
| Molar Mass | 186.25 |
| Density | 1.038±0.06 g/cm3(Predicted) |
| Melting Point | 55 °C |
| Boling Point | 339.2±15.0 °C(Predicted) |
| Specific Rotation(α) | -147°(C=0.674,pyridine)，-21.4°（c=0.11,pyridine） |
| Flash Point | 172.8°C |
| Solubility | Easily soluble in methanol, ethanol, chloroform and ether, slightly soluble in acetone, hardly soluble in water |
| Vapor Presure | 6.5E-06mmHg at 25°C |
| Appearance | White to off-white (Solid) |
| Color | White to Pale Beige |
| pKa | 4.78±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Sensitive | Sensitive to heat |
| Refractive Index | 1.465 |
| MDL | MFCD00204506 |
| Physical and Chemical Properties | A white crystal with a melting point of 58~59 ℃, stable properties, easily soluble in methanol, ethanol, chloroform and ether, slightly soluble in acetone, hardly soluble in water, acidic to litmus paper, rapid fading of bromine water, fading of potassium permanganate solution, but not purplish red to ferric chloride. |
10-HYDROXY-2-(E)-DECENOIC ACID - Reference Information
| introduction | royal jelly is a kind of milky white or light yellow, slightly sweet and slightly sour viscous liquid secreted by nutrient glands of worker bees head. it has physiological effects such as enhancing body resistance, antibacterial and anti-inflammatory, and has high nutritional value. Therefore, royal jelly has been widely valued by people. As early as 1888, the general components of royal jelly were discussed, and it was recognized that most of the royal jelly ether extract was an organic acid with no optical activity, and the chemical formula was C10H18O3. This organic acid was identified as 10-Hydroxy-2-decenoic acid, confirmed to have a trans structure. 10-Hydroxy-2-decenoic acid is unique to royal jelly, so it is often called royal acid (roaljelly). |
| physical and chemical properties | a white crystal with a melting point of 58~59 ℃, stable properties, easily soluble in methanol, ethanol, chloroform and ether, slightly soluble in acetone, hardly soluble in water, acidic to litmus paper, rapid fading of bromine water and fading of potassium permanganate solution, but it does not show purple red for ferric chloride. |
| use | royal acid, as a substance with various physiological activities, is often used to measure the quality of royal jelly, and is also widely used in health food and beverages. it has special effects in treating certain diseases, it also has the ability to regulate and improve the body's immune function and resist radiation injury. A large number of antibacterial tests show that pure bee king acid has strong antibacterial effect on Escherichia coli and pyogenic cocci. Domestic studies have also shown that the combination of bee king acid, chemotherapy and radiotherapy for patients with malignant tumors has a significant effect on immunity, increasing white blood cells and improving clinical symptoms. Studies at home and abroad have also shown that bee king acid has obvious preventive and medical effects on acute radiation. In view of the medical effect of royal jelly, the content of royal jelly has always been the main index to measure the internal quality of royal jelly. Japan has also adopted this index since 1980 and stipulated that the content of royal jelly in imported royal jelly should not be less than 1.9%. The nutritional value and medical value of queen bee acid have been continuously confirmed, and people's understanding of it has been deepened. The demand for food and medicine has increased sharply. Therefore, the production of queen bee acid has a very broad prospect. |
| physiological activity | royal acid has a variety of physiological activities, it has antibacterial, sterilization, strong body and strong inhibition of lymphoma, breast cancer and other cancer cells. It also enhances the body's immune function, prevents hair loss, and is used as a synergist for cosmetics, and is also used to treat acute radiation injury and chemical damage. Therefore, queen bee acid and its products are the best supplements for the elderly, cancer patients and chemical workers. 1) Treatment of acute radiation injury: The experiment of bee king acid against acute radiation injury is to use three groups of mice, divided into prevention group, treatment group and control group, respectively, taking bee king acid before irradiation, and taking bee king acid after irradiation And not taking bee king acid, the feeding conditions of the three groups are the same, the mice were irradiated with cobalt 60 gamma rays 154.8 × 10-4C/kg, and the survival of the mice was observed for 30 days. The results showed that the prevention group could increase the survival rate 44.5%, and the treatment group could increase the 33.4% rate and prolong the average life span of dead mice. The nitrogen content of liver, spleen and kidney of irradiated mice showed that the contents of RNA and DNA in mice were significantly reduced after irradiation, while the contents of these important substances were significantly increased after feeding royal jelly. It can be seen that royal acid can protect and restore the core substances of life-proteins, ribonucleic acid and deoxyribonucleic acid in the internal organs, which reduces the mortality of the irradiated mice. 2) Cell regulation function: When rats take a certain dose of bee king acid every day, the micro-viscosity of the red blood cells of the rats will decrease, and the membrane fluidity will increase, which improves the deformability of the cells, reduces the fragility, and improves the body's regulation Function to prevent lesions. Therefore, the good therapeutic effect of bee king acid on hyperlipidemia, cirrhosis, and cell anemia is based on experiments and molecular basis. 3) Anti-cancer effect: Queen's acid can completely antagonize the inhibitory effect of cortisone on the clearance rate of mouse carbon particles, and can antagonize the inhibitory effect of cyclophosphamide on the delayed hypersensitivity of mouse skin, and can promote cyclophosphamide-induced immune function inhibits the formation of hemolysin in mice, but has no obvious effect on the above-mentioned immune function of normal mice. It can increase the content of white blood cells and reduce triglycerides in plasma and increase the content of free fatty acids. |
| preparation | Grignard reagent method: using hexanediol as raw material, 5- [(tetrahydro-2-furan) oxygen] amyl chloride is used as Grignard reagent to open the ring of β-vinyl-β-lactone, after acid treatment, add alkali to shift the double bond, royal bee acid can also be obtained, and its synthetic route is: |
Last Update：2024-04-09 21:11:58
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Product Name: E－10－hydroxy－2－decylennic acid Visit Supplier Webpage Request for quotationCAS: 14113-05-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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